Clifford Wymer developed a system called WYSEA (Wymer System Estimation and Analysis) using Hartran on the Chilton Atlas from as early as 1965.
WYSEA is a set of programs for the estimation, dynamic analysis, forecasting and simulation of difference or differential equation systems.
Although initially written in Hartran, WYSEA was later modified to standard Fortran.
It was later ported to the ICL 1906A and various IBM and CDC systems and even a Burroughs B7800 at the International Monetary Fund.
WYSEA allows the estimation of models derived from economic theory, hypothesis testing within these models, and their use for dynamic analysis, simulation and forecasting.
Some of the programs in the suite are:
Clifford Wymer is still (2017) active in the area; a recent paper is:
A Macro-Economic Policy Model of the United Kingdom 1855-2014 with Investment, Share Prices and 'Animal Spirits'. Clifford R Wymer, Sapienza University of Rome.